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ALD

ALD

What is Adrenoleukodystrophy?

Adrenoleukodystrophy (ALD) is a rare, genetic disorder characterized by the breakdown or loss of the myelin sheath surrounding nerve cells in the brain and progressive dysfunction of the adrenal gland. ALD is one of a group of genetic disorders called the leukodystrophies that cause damage to the myelin sheath, the fatty covering -- which acts as an insulator -- on nerve fibers in the brain.

There are several forms of ALD. Onset of the classic childhood form, which is the most severe and affects only boys, may occur between ages 4 and 10. Features of this form may include visual loss, learning disabilities, seizures, dysarthria (poorly articulated speech), dysphagia (difficulty swallowing), deafness, disturbances of gait and coordination, fatigue, intermittent vomiting, melanoderma (increased skin pigmentation), and progressive dementia. The most common symptoms are usually behavioral changes such as abnormal withdrawal or aggression, poor memory, and poor school performance.

In the milder adult-onset form, which typically begins between ages 21 and 35, symptoms

ald, form, symptoms, progressive, include, poor, brain, tone, stiffness, spastic, sheath, seizures, paraparesis, onset, nerve, myelin, muscle, mild, lower, loss, genetic, forms, dysfunction, disorder, deterioration, classic, childhood, between, ataxia, ages, affects, adult-onset, adrenal, years, women, within, withdrawal, weakness, vomiting, visual, useful, urinary, typically, treatment

treatment, therapy, symptomatic, swallowing, surrounding, supportive, support

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